Scott W. Walsh, Ph.D.
Professor and Chief, Division of Reproductive Biology Research
Department of Obstetrics and Gynecology
Virginia Commonwealth University
1101 E. Marshall Street
Sanger Hall, Room 11-039
Richmond, VA 23298-0034
Dr. Walsh’s research interests concern immunologic, lipidomic and epigenetic mechanisms as they relate to the pregnancy complications of preeclampsia and preterm labor.
- To develop a state-of-the-art detection system based on photonics using Raman spectroscopy to identify bioactive lipids in maternal blood and urine for real-time assessment of placental function throughout pregnancy. The initial focus is to identify a “lipid fingerprint” early in pregnancy that will predict women who will go on to develop preeclampsia.
- To determine the immunological role of neutrophils and the pregnancy specific expression of protease-activated receptor-1 (PAR-1) as a cause of vascular dysfunction, placental dysfunction, inflammation and enhanced vascular reactivity in preeclampsia. These studies may provide new strategies for treatment with PAR-1 inhibitors by identifying a key molecular target.
- To understand epigenetic and commensal bacterial mechanisms that may explain why African Americans have higher incidences of premature birth and low-birth-weight infants than other ethnic groups.
- Cell and tissue culture
- collection of samples from pregnant patients
- confocal microscopy
- Western blot
- DNA and RNA sequencing
- DNA methylation
- myograph experiments.
NIH, U01 HD087198, “The Utilization of Photonics Technology to Rapidly Detect Bioactive Lipids Associated with Preeclampsia Development”, Multi PI’s (Chalfant, Walsh, Wijesinghe) 09-17-2015 to 08-31-2019
NIH, P60 MD002256; “VCU NIMHD Comprehensive Center of Excellence”; Multi PI’s (Strauss, Jefferson, York, Walsh, Coney); 05/16/12 to 04/30/17.
- Estrada-Gutierrez G, Cappello R, Mishra N, Romero R, Strauss III JF, Walsh SW. Increased expression of matrix metalloproteinase-1 in systemic vessels of preeclamptic women: A critical mediator of vascular dysfunction. Am J Pathol, 178: 451-460, 2011
- Mishra N, Nugent WH, Mahavadi S, Walsh SW. Mechanisms of enhanced vascular reactivity in preeclampsia, Hypertension, 58: 867-873, 2011
- Mousa AA, Strauss III JF, Walsh SW. Reduced methylation of thromboxane synthase gene is correlated with its increased vascular expression in preeclampsia. Hypertension, 59: 1249-1255, 2012
- Mousa AA, Archer KJ, Cappello R, Estrada-Gutierrez G, Isaacs CR, Strauss III JF, Walsh SW. DNA methylation is altered in maternal blood vessels of preeclamptic women. Reprod Sci, 19: 1332-1342, 2012
- Nugent WH, Mishra N, Strauss III JF, Walsh SW. Matrix metalloproteinase-1 causes vasoconstriction and enhances vessel reactivity to angiotensin II via protease activated receptor-1. Reprod Sci, 23: 542-548, 2016
List of Published Work in MyBibliography: http://tinyurl.com/scottwwalsh
- Sonya L. Washington, M.S., Lab Specialist and Research Coordinator
- Sheikh M. Khorshed Alam, Ph.D., Postdoctoral fellow
- Rita Schwartzwelder, B.S., Lab technician